Keppra And CBD Oil Interaction

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Hello, This is my first time on the forums and looking for some advice. My son is 8 years old and has had mild seizures in the early morning while sleeping. They are not so often, maybe every 2 months. He has heavy breathing and sometimes shaking of the arms. He has also had an EEG and it wasn't great. Anyway, he has been on Keppra medicine and we are not convinced it is doing Keppra And CBD Oil Interaction Pharmacokinetic and pharmacodynamic interactions occur with multiple ASMs. Pharmacokinetic interactions are frequently attributed to CYP2C19 and CYP3A4. Known

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Hello, This is my first time on the forums and looking for some advice. My son is 8 years old and has had mild seizures in the early morning while sleeping. They are not so often, maybe every 2 months. He has heavy breathing and sometimes shaking of the arms. He has also had an EEG and it wasn’t great. Anyway, he has been on Keppra medicine and we are not convinced it is doing anything for controlling the attacks because they are more or less the same as they were before taking Keppra. Our neurologist suggested taking a higher dose, so we did it, but they still are the same. So, we are considering slowly using CBD (10%) oil and wean him slowly off Keppra. I was wondering what your thoughts are on this? Our doctor is against CBD and says it won’t work. I am not convinced about his negative attitude and response. Any ideas would be great. Thank you

Comments

Hi, Thank you for posting and
Submitted by Anonymous on Mon, 2020-02-24 – 09:24

Hi, Thank you for posting and we understand your concerns. Treatment and how they body may react to certain medications varies for each individual. To learn more about CBD oil, please visit: https://www.epilepsy.com/learn/treating-seizures-and-epilepsy/other-treatment-approaches/medical-marijuana-and-epilepsy .Prior to making any changes to your son’s individual treatment plan, it’s important that you all are following-up with your son’s healthcare team to continue to express your concerns and frustrations regarding his medication and seizure control. It’s also important to address any changes in seizure types, frequency, side effects, symptoms, moods and behaviors to determine what individual treatment plan is best for him. You all may want to consider keeping a journal or diary. My Seizure Diary: https://www.epilepsy.com/living-epilepsy/epilepsy-foundation-my-seizure-diary ,is a great tool for tracking & identifying seizures, setting reminders, managing medications & side effects, recording medical history, moods, behaviors, triggers, and therapies, that may affect seizures and wellness, which can be shared with his doctors. It can be challenging to find a healthcare team that you’re comfortable working with. If you feel you cannot talk openly with his doctors or that you aren’t working towards the same goals, it may be time to get a second opinion. https://www.epilepsy.com/learn/diagnosis/you-and-your-healthcare-team/second-opinionsIf you have not already, you all may want to consider having your son see an epileptologist, (epilepsy specialist), for assistance find an epileptologist near you, please visit: www.epilepsy.com/living-epilepsy/find-epilepsy-specialistIt’s common for those who are in caregiver role to feel overwhelmed. It’s important to remember that you are not alone, and that you’re and making your health and overall well-being a priority. https://www.epilepsy.com/sites/core/files/atoms/files/Caregivers%20factsheet.pdf It may also be helpful to connect with other parents who may have similar experiences, to ask questions, find & give support to each other,by visiting: https://www.epilepsy.com/living-epilepsy/parents-and-caregivers/parents-helping-parents Additionally, you may always contact our 24/7 Helpline, where trained information specialists are available to answer your questions, offer help,hope, support, guidance, and access to national and local resources. 1-800-332-1000, or [email protected] epilepsy.com/helpline

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Hi, Thank you for posting and we understand your concerns. Treatment and how they body may react to certain medications varies for each individual. To learn more about CBD oil, please visit: https://www.epilepsy.com/learn/treating-seizures-and-epilepsy/other-treatment-approaches/medical-marijuana-and-epilepsy .Prior to making any changes to your son’s individual treatment plan, it’s important that you all are following-up with your son’s healthcare team to continue to express your concerns and frustrations regarding his medication and seizure control. It’s also important to address any changes in seizure types, frequency, side effects, symptoms, moods and behaviors to determine what individual treatment plan is best for him. You all may want to consider keeping a journal or diary. My Seizure Diary: https://www.epilepsy.com/living-epilepsy/epilepsy-foundation-my-seizure-diary ,is a great tool for tracking & identifying seizures, setting reminders, managing medications & side effects, recording medical history, moods, behaviors, triggers, and therapies, that may affect seizures and wellness, which can be shared with his doctors. It can be challenging to find a healthcare team that you’re comfortable working with. If you feel you cannot talk openly with his doctors or that you aren’t working towards the same goals, it may be time to get a second opinion. https://www.epilepsy.com/learn/diagnosis/you-and-your-healthcare-team/second-opinionsIf you have not already, you all may want to consider having your son see an epileptologist, (epilepsy specialist), for assistance find an epileptologist near you, please visit: www.epilepsy.com/living-epilepsy/find-epilepsy-specialistIt’s common for those who are in caregiver role to feel overwhelmed. It’s important to remember that you are not alone, and that you’re and making your health and overall well-being a priority. https://www.epilepsy.com/sites/core/files/atoms/files/Caregivers%20factsheet.pdf It may also be helpful to connect with other parents who may have similar experiences, to ask questions, find & give support to each other,by visiting: https://www.epilepsy.com/living-epilepsy/parents-and-caregivers/parents-helping-parents Additionally, you may always contact our 24/7 Helpline, where trained information specialists are available to answer your questions, offer help,hope, support, guidance, and access to national and local resources. 1-800-332-1000, or [email protected] epilepsy.com/helpline

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Hi, Thank you for posting and we understand your concerns. Treatment and how they body may react to certain medications varies for each individual. To learn more about CBD oil, please visit: https://www.epilepsy.com/learn/treating-seizures-and-epilepsy/other-treatment-approaches/medical-marijuana-and-epilepsy .Prior to making any changes to your son’s individual treatment plan, it’s important that you all are following-up with your son’s healthcare team to continue to express your concerns and frustrations regarding his medication and seizure control. It’s also important to address any changes in seizure types, frequency, side effects, symptoms, moods and behaviors to determine what individual treatment plan is best for him. You all may want to consider keeping a journal or diary. My Seizure Diary: https://www.epilepsy.com/living-epilepsy/epilepsy-foundation-my-seizure-diary ,is a great tool for tracking & identifying seizures, setting reminders, managing medications & side effects, recording medical history, moods, behaviors, triggers, and therapies, that may affect seizures and wellness, which can be shared with his doctors. It can be challenging to find a healthcare team that you’re comfortable working with. If you feel you cannot talk openly with his doctors or that you aren’t working towards the same goals, it may be time to get a second opinion. https://www.epilepsy.com/learn/diagnosis/you-and-your-healthcare-team/second-opinionsIf you have not already, you all may want to consider having your son see an epileptologist, (epilepsy specialist), for assistance find an epileptologist near you, please visit: www.epilepsy.com/living-epilepsy/find-epilepsy-specialistIt’s common for those who are in caregiver role to feel overwhelmed. It’s important to remember that you are not alone, and that you’re and making your health and overall well-being a priority. https://www.epilepsy.com/sites/core/files/atoms/files/Caregivers%20factsheet.pdf It may also be helpful to connect with other parents who may have similar experiences, to ask questions, find & give support to each other,by visiting: https://www.epilepsy.com/living-epilepsy/parents-and-caregivers/parents-helping-parents Additionally, you may always contact our 24/7 Helpline, where trained information specialists are available to answer your questions, offer help,hope, support, guidance, and access to national and local resources. 1-800-332-1000, or [email protected] epilepsy.com/helpline

You hold your baby close like
Submitted by Plan-To-Succeed on Tue, 2020-03-17 – 22:03

You hold your baby close like my mom did to me and even if the seizures stay the same or don’t change threw his life if he loses you every spot in the body that a beat and puals will only have the feeling of moms heart from the hugs because mom held the baby enough and I feel saved from her because of this even crying with me at times of most feared so you may give best outlook threw love.

You hold your baby close like my mom did to me and even if the seizures stay the same or don’t change threw his life if he loses you every spot in the body that a beat and puals will only have the feeling of moms heart from the hugs because mom held the baby enough and I feel saved from her because of this even crying with me at times of most feared so you may give best outlook threw love.

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You hold your baby close like my mom did to me and even if the seizures stay the same or don’t change threw his life if he loses you every spot in the body that a beat and puals will only have the feeling of moms heart from the hugs because mom held the baby enough and I feel saved from her because of this even crying with me at times of most feared so you may give best outlook threw love.

Keppra And CBD Oil Interaction

Pharmacokinetic and pharmacodynamic interactions occur with multiple ASMs.

Pharmacokinetic interactions are frequently attributed to CYP2C19 and CYP3A4.

Known interactions may not alter the ASM level outside the therapeutic range.

There is limited evidence currently for many ASMs.

There is limited evidence for the clinical relevance of many interactions.

Abstract

Objective

Cannabidiol is efficacious as an adjunctive treatment in children with epilepsy associated with Dravet and Lennox-Gastaut syndromes. As its role is currently adjunctive, we reviewed the interactions of cannabidiol with other antiseizure medications (ASMs).

Methods

A search of Cochrane, Pubmed and Embase databases from January 2015 to April 2020 was performed. All original research papers discussing interactions between cannabidiol and ASMs were included. Bibliographies of review articles were searched to identify further papers. Adverse events and side effects were excluded.

Results

Cannabidiol interacts with ASMs through both pharmacokinetic and pharmacodynamic mechanisms. Thirty studies were identified (eighteen observational cohort studies, two randomised-control trials, three case reports/series, three animal studies, two briefing reports, an analysis of cohort data and a clinical trial simulation). There is potential for pharmacokinetic interactions between CBD and brivaracetam, clobazam, eslicarbazepine, lacosamide, gabapentin, oxcarbazepine, phenobarbital, potassium bromide, pregabalin, rufinamide, sirolimus/everolimus, stiripentol, tiagabine, topiramate and zonisamide. Pharmacodynamic interactions were identified for clobazam, valproate and levetiracetam. An animal study identified that the brain concentration of ASMs may be altered while the serum concentration remains the same.

Conclusion

Pharmacokinetic and pharmacodynamic interactions exist between cannabidiol and ASMs. The cytochrome p450 system in particular has been implicated in pharmacokinetic interactions, although not exclusively. The existing literature is limited for some ASMs by studies having relatively small cohorts. As increasing numbers of patients use cannabidiol, specialists need to monitor closely for interactions clinically and with blood levels when required.

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