CBD Oil And Viagra Interaction

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Among the benefits of CBD oil, treating factors leading to erectile dysfunction is one among them. Find out how to use CBD oil for erectile dysfunction & if you can use it with Viagra. In general, cannabis can be helpful for male sexual function, including getting and maintaining an erection CBD can interact with many medications, including sildenafil (Viagra). Read on to learn if you can take CBD oil together with Viagra.

CBD Oil for erectile dysfunction: Can you take CBD oil with Viagra?

As CBD oil expands into many markets around the globe, it seems it may also be emerging as a male sexual health treatment. For erectile dysfunction (ED) to be specific. Let us find answers to your questions like How to use cbd oil for erectile dysfunction? Can I take CBD oil with Viagra?

About 4.3 million men in the UK are affected by ED. However, 44% of men do not seek any medical help. In the interests of being discreet, they sometimes purchase fake products. Their need for privacy often ends up increasing anxiety and exacerbating their performance in the bedroom.

CBD oil and erectile dysfunction may seem unlikely allies on paper. However, there is some evidence to suggest CBD can help alleviate symptoms of ED.

Although, compared with the effects of viagra, it may seem less potent. However, we have reasons to believe it may be a healthier option.

Table of Contents

CBD oil and Viagra – Which is better for erectile dysfunction?

CBD oil still isn’t yet widely considered strong competition to Viagra for treating erectile dysfunction. Most people are unaware of CBD’s potential to enhance their sex life.

Viagra is still the most popular medication for ED. It also helps in having a satisfactory sexual experience. The benefits of CBD in treating erectile dysfunction are not as widely acknowledged as Viagra. There is also little research to support the latter as well.

However, Viagra can cause significant side effects. Its use is strongly associated with cardiovascular diseases. This makes the medicine unviable for long-term use. Particularly, in older men who tend to be the cohort that seeks it the most.

Dr Perry Solomon, Chief Medical Officer at HelloMD, suggested in 2016, “The way I see it, why not try cannabis? There are side effects to Viagra and zero side effects to cannabis when dosed properly. Maybe it’s just making them feel better and relaxed, and that’s making it easier for them to enjoy sex, but it’s still working.”

Research is still underway to study the effect of CBD on men’s libido. Researchers have acknowledged the presence of an endocannabinoid system and the effect CBD has on it.

CBD’s effect on anxiety and its relaxation benefits are widely acknowledged. A survey taken by 1,000 people, revealed that 68% of the people had an improved sexual experience. Others said that it helped them relax and improved their mood.

Whether CBD can directly cure ED has to be put to scientific inquiry. But there is enough research to suggest that it can improve several symptoms that lead to ED.

What does the research say about CBD oil and Erectile Dysfunction?

Erectile dysfunction is commonly associated with old age. However, this is a myth. It can manifest as reduced libido or inability to have an erection at any age.

ED has also been associated with:

  • Anxiety
  • Cardiovascular health
  • Obesity
  • Work stress
  • Addiction to porn etc.

As it turns out, research is being conducted that strives to prove that CBD can relieve these potential factors that contribute to ED.

CBD for anxiety-related ED

There is ample evidence to suggest that ED can be caused by anxiety. ED sufferers reveal bouts of increased stress, deadlines, relationship issues impacting their lack of interest in sex contributing to reduced libido. Moreover, depressed men are often reported to experience erectile dysfunction.

For ages, CBD has been touted as an effective medicine to counter anxiety.

Its effect on the endocannabinoid system – and the entourage effect -is widely recognised by researchers. Owing to this, CBD products are used to relieve anxiety and stress and induce sleep.

From the perspective of treating ED-related anxiety, CBD can be quite useful to fight anxiety levels that can impact your libido. This is further accentuated by sex educator, Diana Urman:

“Many people say they feel more spontaneous and adventurous [after using CBD]…There is also sometimes an increased sensitivity to touch and increased willingness to be more engaged and sensual which, in turn, enhances sexual pleasure and deepens orgasmic abilities.”

CBD for better cardiovascular health

CBD can also alleviate erectile dysfunction by contributing to a healthier heart. This is its greatest value proposition to take on the likes of Viagra. With the latter raising the risks of acquiring cardiovascular diseases, CBD is seen as its effective alternative.

One of the symptoms of cardiovascular diseases is erectile dysfunction. Although mental health may be a factor for younger men, older men can suffer from ED due to a weak cardiovascular system. A poor heart means poor blood flow into the penis, which in turn causes erectile dysfunction.

There is significant research on CBD and its impact on the entire cardiovascular system and CBD and vasodilation. Both streams suggest that CBD helps in widening arteries and veins which leads to better flow of blood.

For sufferers of erectile dysfunction, CBD oil can offer relief by strengthening their circulatory system. This leads to an increased flow of blood throughout the body helping your erections as well.

CBD and obesity-related ED

1 in 4 people in the UK suffers from obesity.

Along with heart diseases, obesity can also play a role in erectile dysfunction. This happens when fat tissues in the body overcharge CB receptors which contribute to obesity and metabolic risks. Moreover, obesity can also affect testosterone levels making it difficult to have erections.

Here is how CBD proves to be useful.

Research surrounding CBD and its effect on various obesity factors does exist. Although the scientific community is still out on this, studies on animal test subjects (rats) showed that CBD reduced cholesterol by 25%. The therapeutic compound blocks off CB1 receptors and stimulates CB2 receptors, in effect, reducing the risk of obesity.

Moreover, a study in 2016 backed up a claim that CBD can turn “bad fat into good fat”. Proponents claim that using CBD, white, or “bad,” fat can be turned into brown fat, which may help the body burn calories. The study also pointed out that CBD helps in breaking down fats more efficiently.

In this way, CBD can combat obesity-related erectile dysfunction.

How to use CBD oil for Erectile Dysfunction?

Now that you know how CBD can help with ED, you might be curious to know how to use it to strengthen your love life. It is important to note that every person is different and that you might have to experiment with a couple of different products and variations to find the one that works best for you.

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With a myriad of ways to consume CBD, we have filtered the list down to the two most practised and effective ways to take CBD for ED.

1. CBD tinctures and edibles

In general, this is the most popular way to consume CBD. With edibles, you can ingest your CBD in whatever way you like. You have CBD brownies, CBD gummy bears, CBD honey, CBD tea and CBD coffee. You can even prepare your own food with CBD oil.
Many people find edibles an excellent means to help manage their stress and anxiety levels. The reason for this is that edibles slowly release and allow you to experience the calming effects of CBD over a long period of time.

CBD edibles could indirectly help solve erectile dysfunction especially if it is caused by anxiety. Put simply, it may reduce the anxieties you hold towards the act of sex. Without these fears it can be easier to become erect.

However, there can be some issues. The issue with taking edibles is that they can take a while to come into effect. So, unfortunately, edibles are not the best option if sexual spontaneity is your game. Edibles are a better idea for romantic and sexual nights that you have prepared beforehand. This is so you can consume the edibles prior so that they have time to enter the bloodstream and help you get erect.

If you are looking for a faster acting edible, CBD tinctures could be for you. With CBD tinctures or oil you can add a few drops under your tongue and hold it there for 1 – 3 minutes. This allows the CBD to enter your bloodstream faster. The tincture directly enters your bloodstream from the capillaries under the tongue rather than taking the long way round through the digestive system.

2. CBD massage oil as a lubricant

Lubricant infused with can be a direct way to help with ED. CBD creams and oils are usually used to help relieve pain all over your body. With that in mind, these creams can be used on your genitals also.

People frequently use CBD as a massage oil for its relaxing properties. Also, many of us experiment with other massage oils to add an air of romance to our sex lives.

So why not try CBD oils as a lubricant? It can be directly applied to the testicles and penis and can possibly help you with ED.

CBD lube also has other added benefits. CBD oil can help reduce friction during sexual intercourse. This obviously allows for more comfortable sex for both persons. However, in addition, it can allow men to last longer during sex. This is due to the lubricant reducing sensitivity.

Anecdotally, some claim that CBD lubricant can aid in bringing about a more intense sensation during orgasm.

Although, most suggest that CBD lubricants are helpful with ED. It is important to note that some claim that CBD reduces their sex drive. This issue seems more prevalent for women.

Trying for yourself

As we said before, each person is different and different methods of CBD work better for some than others. Our advice would be to experiment around. If you want to avoid using Viagra and want to try CBD may be a mixture of edibles and CBD lube works well for you.

However, we encourage you to use CBD responsibly and if you are new to taking CBD, you should start off slow. With edibles take a small dose and work your way up to a dose appropriate to your needs. With CBD lube, you should follow the instructions given with the product you buy.

Can I take CBD oil with Viagra?

In short, we recommend you not to use CBD and Viagra together.

Currently, there is little evidence to show how CBD and Viagra interact and it is best to avoid using the two simultaneously until more research is done on the topic.

One reason why we recommend not to use the two together is that Viagra is a PDE 5 inhibitor. PDE 5 inhibitors and CBD both can reduce blood pressure. And if you do not have high blood pressure two substances lowering your blood pressure should be avoided.

Secondly, although there is no evidence as of yet, CBD may react with Viagra. The reaction may then weaken or stop the effects of Viagra.

If you are still unsure whether you should take CBD and/or Viagra, ask your doctor. Your doctor can help you understand whether CBD could help you and whether it is a good idea to take CBD with Viagra. But ultimately, we recommend you should stay away from the combination unless a medical professional clears you to do so.

So what’s the catch?

CBD, as an ingredient to use edibles and topical applications that boost your mood, is declared completely safe by the World Health Organisation. Many experts believe that CBD is safe to use as long as it is taken in appropriate dosages.

However, too much CBD can sometimes have counterintuitive effects. A few studies suggest that increased use of CBD may actually result in ED despite increasing sexual desire.

Conclusion

With its psychological advantages, CBD is seen as an effective alternative to Viagra. CBD can relieve anxiety and clear your mind to have a healthy sex life. However, its physiological impacts and benefits to treat erectile dysfunction still require more research.

With the expanding CBD market, we believe that the conclusion is just around the corner. Until then, remember to take CBD in moderation.

Cannabis and Viagra: is it a safe combination?

In general, cannabis can be helpful for male sexual function, including getting and maintaining an erection, but also for men with low libido and those who experience early finish.

Viagra is used to treat erectile dysfunction – that’s a well-known fact. Not so commonly known is that patients will not get an erection just by taking a little blue pill. Rather, Viagra helps a man get and keep an erection only when he is sexually stimulated.

With that in mind, cannabis directly targets the libido, increasing feelings of arousal by cannabinoids sending neurotransmitters to the brain, interacting with the endocannabinoid system (ECS) that monitors pleasure and relaxation, and ultimately heightening the two.

“Cannabis and the PDE-5 inhibitors – Viagra and Cialis, for example, that relax muscles and increase blood flow to the penis – are generally safe to use together,” says Jordan Tishler, MD, who is on the faculty at Harvard Medical School, president of the Association of Cannabinoid Specialists, and CEO/CMO at inhaleMD, a patient-focused clinical practice.

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“There is some evidence that THC can interact with Cialis (Tadalafil) specifically but I’ve never seen it become a real-world problem,” he says.

Tishler goes on to explain that this means some interactions are theoretical (based on the biology) but don’t seem to actually occur in the real world (or at least not noticeably). “I’ve never seen a cannabis-related Cialis adverse event. Could happen, but doesn’t seem to come up.”

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However, says Tishler, “cannabis is very dose dependent. A little can be helpful, but too much can backfire and shut down sexual experience. For men with erectile dysfunction (ED), cannabis in too high a dose can cause loss of erection. Overall, cannabis can be wonderfully helpful, but is really best done in conjunction with medical guidance to avoid pitfalls.”

Viagra and cannabis have the potential to work together. However, it is worth noting that Viagra is predominantly metabolized by an liver enzyme known as CYP3A4, which can be inhibited by CBD. This means that when taken together, the effects of sildenafil (Viagra) could be increased, increasing the risk of side effects like headaches and dizziness. 1

Since little research focuses on the specific topic of inhibitors as well as men’s sexual wellness and health in general, more research is needed.

Erectile dysfunction, underlying issues and cannabis

Sexual arousal involves the brain, hormones, emotions, nerves, muscles and blood vessels, and ED can result from a problem with any of these. Stress can also be a trigger. Often, it is a combination of physical and psychological issues. Cannabis can help.

The endocannabinoid system helps to regulate erectile function and sexual behavior of males through the binding of receptors in the paraventricular nucleus of the hypothalamus, among other locations. 2

This could also explain why cannabis can improve sexual function in some patients affected by conditions or symptoms such as depression, anxiety disorder and pain. 3 4

Growing evidence, both in animal and human studies, reported a peripheral effect of cannabis on ED, specifically on corpus cavernosum, the erectile tissue forming the bulk of the penis, where cannabinoid receptors are present. 5 6

Not all of the research is in agreement, though. There are some studies associating cannabis-use orgasm disorders in men. In fact, both the inability to finish and finishing too quickly were associated with cannabis use in one survey of Australian men. It remains unclear if this is cannabis related or if common tobacco use alongside cannabis is confounding (altering) this finding. 7

But most agree that the right dose of cannabis can turn an ordinary experience into an extraordinary one – and that includes a sexual experience.

In fact, according to a 2021 review article looking at cannabis and male reproductive health “some studies have suggested that 70–85% of marijuana consumers experience increased sexual pleasure and satisfaction, 25–40% prolonged duration of intercourse, and 55–70% heightened orgasmic sensation.” 8

THC can slow down time and intensify feelings of sexual pleasure while CBD reduces stress, lessens anxiety and may even relieve depression by activating serotonin receptors in the brain. 9

Some studies suggest cannabis use even increases testosterone levels. However, other studies have found the opposite effect on testosterone and also suggest that THC is a bit of a passion killer (dosage is key, less is better). More research needs to be conducted, including human trials.

Can cannabis replace Viagra? It probably can’t for the majority of men, but the combination can ensure sexual desire, arousal, orgasm and overall satisfaction.

CBD and Viagra (Sildenafil) Interactions: Do They Mix?

CBD (or cannabidiol) is primarily used for anxiety, depression, chronic pain, and sleep — but it also offers a wide range of other therapeutic effects.

Some people report increased effectiveness of sildenafil (Viagra) after taking CBD oil — helping improve erection and reduce worries linked to performance anxiety.

But can you safely take CBD oil with Viagra?

That’s the question we’ll answer in this article.

Does CBD Interact with Sildenafil?

Yes, and you should exercise caution when taking CBD oil with sildenafil (Viagra).

The main danger of combining CBD with Viagra is associated with an increased risk of side effects. Although uncommon, Viagra can trigger indigestion, dizziness, headaches, and priapism — a condition involving painful and long-lasting erections.

CBD may also extend the effects of Viagra by slowing down its metabolism.

Types of Interactions Between CBD and Viagra (Sildenafil)

CBD’s ability to inhibit the activity of liver enzymes creates a risk of negative interactions because it alters drug metabolism.

You can experience two types of interactions between CBD and Viagra depending on the dosage.

A) Agonistic Interaction (Increased Effect)

An agonistic interaction occurs when two compounds have the same effects on the body. When it comes to taking CBD and sildenafil together, they share the ability to relax blood vessels. Combined doses of both substances may lead to excessive relaxation, including headaches, dizziness, fatigue, and the aforementioned priapism.

B) Slowed Elimination (Metabolic Inhibition)

Drugs are metabolized in the body through special enzymes known as the Cytochrome P450 (CYP450) family.

Metabolic inhibition is triggered when two drugs target the same enzymes — leading to competitive interactions. In other words, taking CBD with Viagra could result in slowing down the metabolism of one of the drugs.

Sildenafil uses CYP450 enzymes, specifically CYP3A4 (major route) and CYP2C9 (minor route). CBD is a potent inhibitor of these enzymes.

If you take CBD with sildenafil, the plasma levels of the drug can increase in the body. When you use viagra on a daily basis, the continuous buildups of the substance could become dangerous.

You can avoid it by spacing out the time between your doses so that your body can flush them.

Other Names for Viagra (Sildenafil)

Sildenafil is an umbrella term for a pharmaceutical compound that is used to treat erectile dysfunction.

It has many different brand names, such as:

  • Alsigra
  • Aryagra
  • Caverta
  • Edegra
  • Giagra
  • Medigra
  • Penegra
  • Revatio
  • Silagra
  • Vega
  • Vizarsin
  • Xcite
  • Zenegra

Does CBD Oil Interact with Other Erectile Dysfunction Medications?

In general, always look out for unintended interactions between CBD and other medications. Since CBD and erectile dysfunction medications (PDE5 inhibitors) are metabolized by the same enzymes, they share a similar risk for interaction.

The following medications can negatively interact with CBD:

  • Avanafil (Stendra)
  • Mirodenafil (Mvix)
  • Tadalafil (Cialis)
  • Udenafil (Zydena)
  • Vardenafil (Levitra, Staxyn, and Vivanza)

Is It Safe to Take CBD Oil Together With Viagra?

There are no clinical reports of dangerous side effects caused by interactions between CBD oil and Viagra.

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However, it’s wise to maintain caution with one side effect (priapism). Since both substances can relax blood vessels, you’re theoretically at a higher risk of developing this condition.

If you notice any distressing reactions after taking CBD oil with sildenafil, discontinue the use and contact your doctor immediately.

Is CBD a Good Alternative to Viagra (Sildenafil?)

CBD isn’t considered a viable alternative to Viagra because it’s not an acknowledged ED treatment.

CBD and other cannabinoids have demonstrated benefits for ED in some individuals, but this effect is more related to CBD’s impact on anxiety disorders, such as performance anxiety.

VIagra, on the other hand, directly relaxes blood vessels, pumping more blood to the penis. This effect hasn’t been observed in studies investigating the effects of CBD.

If you experience mild ED caused by anxiety, CBD could be a safer alternative to viagra. However, ED triggered by mechanical injuries is unlikely to benefit from CBD.

What is Viagra?

Viagra is one of the brand names for sildenafil — a phosphodiesterase type 5 (PDE5) inhibitor. Doctors prescribe it to treat erectile dysfunction and pulmonary hypertension.

It’s an FDA-approved treatment for ED and is available only for a prescription in most countries.

Viagra (Sildenafil) Details:

Pharmaceutical Name Sildenafil
Brand Names Viagra, Silagra, Alsigra, Aryagra, Edegra, Revatio, Penegra, Xcite, Vega, Giagra, Vizarsin, Zenegra, Caverta
Class of Drug Phosphodiesterase 5 Inhibitor
Metabolic Enzymes Cyp 450 enzymes (CYP3A4 and CYP2C9)
Interaction with CBD Agonistic, metabolic inhibitor
Strength of Interaction Low

How Does Viagra Work for Erectile Dysfunction (ED)?

Sildenafil (Viagra) is the inhibitor of phosphodiesterase 5 (PDE5). Its main mechanism causes an increase in the blood flow to a flaccid penis. This feature enables erection.

PDE5 is an enzyme commonly found in vascular smooth muscles, visceral smooth muscles, platelets, and cavernosa.

Was Viagra Always Used to Treat ED?

Viagra was originally meant to serve a different purpose. It was invented as a potential blood pressure medication. Its side effect, however, made it a preferred drug for ED.

The Mechanism Behind Erection

When you have sex with your partner, an adequate amount of foreplay should lead to a release of nitric oxide (NO) from the nerves and endothelial cells. This event triggers the release of cyclic guanosine monophosphate (cGMP).

The cGMP’s release relaxes the muscles of corpora cavernosa in the penis, dilating the blood vessels. As the blood flows rapidly into those vessels, the penis becomes enlarged and gets erect. This state lasts until the end of the sexual intercourse or after ejaculation.

What Happens When You Take Viagra

The enzyme PDE5 blocks the additional blood flow to the vessels in the penis. It does so by causing the cGMP levels to degrade. In the majority of ED patients, the dysfunction also affects the blood vessels in the penis.

Since Viagra inhibits PDE5 and increases the level of cGMP, it lets more blood flow into the penis, allowing for a successful erection.

With a positive mindset and sufficient sexual stimulation, this drug may be even more effective.

Viagra isn’t recommended for use alongside alcohol. Patients with severe heart disease, priapism, several renal and liver disease, blood disorders, retinitis pigmentosa, and hypersensitivity to sildenafil should steer away from viagra, too.

Although Viagra doesn’t cause dependence and addiction, it can interact with several medications, including antacids, guanylate cyclase stimulators, CYP3A4 inducers, and CYP3A4 inhibitors.

Side Effects of Viagra

  • Abdominal pain
  • Abnormal vision
  • Back pain
  • Diarrhea
  • Dyspepsia
  • Hot flushes
  • Headaches
  • Loss of vision
  • Nausea
  • Skin Rash
  • Muscle pain
  • Bluish tinted vision
  • TIngling sensation in the limbs

What is CBD Oil?

CBD oil is an oily extract derived from cannabis. It can be extracted from hemp and marijuana, but most CBD oils on the market come from hemp. That’s because hemp is legal in all 50 states.

CBD doesn’t get you high, but it comes with a myriad of health benefits. This feature makes CBD an appealing alternative to marijuana. Since THC can make users anxious in higher doses, some of them are afraid of starting the treatment. CBD comes in handy here.

Since CBD is fat-soluble, manufacturers suspend it in a carrier oil. Usually, it’s MCT oil because it contains the highest percentage of saturated fatty acids.

People commonly use CBD oil for pain relief or to reduce anxiety, depression, and sleep problems. However, CBD also has the potential to manage the symptoms of autoimmune diseases and neurological conditions.

In a 2009 article published in the journal Annals of the New York Academy of Sciences, the authors concluded that the endocannabinoid receptors occur in the sexual reproductive organs, such as testicles. They also found them in the brain.

Other studies found that cannabinoids such as CBD and THC may increase libido and improve sex life in general, while others warn that regular cannabis use may lower sex drive in males. However, these studies also involved high-THC cannabis (marijuana).

One of the best-researched areas of the therapeutic use of CBD is anxiety. CBD may improve libido by reducing anxiety disorders, such as performance anxiety — increasing one’s desire for sex.

Final Verdict: Can You Take CBD Oil with Viagra?

CBD can inhibit the metabolism of Viagra in the body — potentially increasing the duration and concentration of the drug in the body.

In addition, CBD may strengthen some of the effects of Viagra, increasing the risk of lightheadedness and painful erection.

Always talk to your doctor before taking CBD oil with Viagra. Doing so will help you find the right dosage and timing for both products and avoid potential interactions.

Sources:

  1. Carvalho, R. K., Andersen, M. L., & Mazaro‐Costa, R. (2020). The effects of cannabidiol on male reproductive system: A literature review. Journal of Applied Toxicology, 40(1), 132-150.
  2. Pizzol, D., Demurtas, J., Stubbs, B., Soysal, P., Mason, C., Isik, A. T., … & Veronese, N. (2019). Relationship between cannabis use and erectile dysfunction: a systematic review and meta-analysis. American journal of men’s health, 13(6), 1557988319892464.
  3. Blessing, E. M., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015). Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics, 12(4), 825-836
Livvy Ashton

Livvy is a registered nurse (RN) and board-certified nurse midwife (CNM) in the state of New Jersey. After giving birth to her newborn daughter, Livvy stepped down from her full-time position at the Children’s Hospital of New Jersey. This gave her the opportunity to spend more time writing articles on all topics related to pregnancy and prenatal care.

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