Taking CBD oil and beta-blockers? Or considering it? Then here's the answer on using both together, or whether CBD oil can replace beta-blockers! A guide! When you take CBD alongside certain medications, it can trigger negative drug interactions. Here we explain what drugs shouldn’t be taken with CBD — and when to consult your doctor if you’re not sure about the potential interactions. Renowned for its recently discovered benefits, CBD oil is of growing interest for cardiovascular health. But can it be used with conventional heart medication?
CBD Oil and Beta-Blockers, Can You Take Both? Here’s What to Do!
Perhaps you’re taking beta-blockers, and you want to know if CBD oil and Beta-blockers can be taken together. Or could CBD potentially replace the need for Beta-blockers?
So, we’re diving into more details around this subject. But here’s the quick answer to get us started.
CBD Oil and Beta-Blockers, what happens? Many take CBD and beta-blockers together to reduce blood pressure levels quickly or reduce/relieve beta-blockers’ side effects by using CBD oil. Doing this results in an unhealthy level of low blood pressure. This is because CBD oil inhibits the body’s ability to metabolize beta-blockers.
Why Are CBD Oil And Beta Blockers Taken Together?
CBD is a natural supplement that has shown effectiveness in controlling and healing a variety of medical conditions. One of the medical conditions that CBD has shown high potential to control is lowering high blood pressure.
CBD alone, with no other medications or supplements, has positive results for patients with high blood pressure.
So, the first and foremost reason patients combine CBD with heart medications like beta-blockers is for high efficacy.
Meaning, many patients combine CBD with beta-blockers to experience an effective reduction of high blood pressure or expect stabilized blood pressure levels throughout the day.
The second and perhaps the most overlooked reason why CBD oils are combined with beta-blockers is to negate the side effects of beta-blockers.
How CBD Oil Helps Relieve the Side Effects of Beta-Blockers
Some of the most common side effects of beta-blockers are nausea and fatigue. Many user experiences believe the use of CBD has a high potential to relieve these common side effects.
However, some users also state, CBD oil may sometimes worsen the side effects of beta-blockers if you take the wrong dose.
CBD oil in general helps to reduce the experience of nausea across a range of health conditions. This can range from general motion sickness to chemotherapy-induced nausea.
Along these lines, some users also make the connection that the use of CBD oil will also help to negate nausea induced by beta-blockers. This is why some will advocate for taking CBD oil if you begin to feel nauseous after taking a beta-blocker.
CBD is also being studied in an ongoing process to assess its effectiveness in promoting wakefulness.
Surprisingly, many studies have concluded that taking smaller doses of CBD oil helps increase wakefulness, alleviating daytime sleepiness caused by factors like sleep apnea, substance abuse, or certain medications.
So, it’s reasonable to say that patients who experience fatigue or drowsiness as a result of beta-blockers may find relief in taking CBD oil along with beta-blockers.
Interactions of CBD Oil and Beta-Blockers
CBD is a natural compound and is generally considered very safe with tolerant compounds. This also makes CBD oil exhibit very few unintended side effects.
However, CBD oil inhibits the cytochrome P-450 enzyme system in the liver. So, because of this, any medications that use this cytochrome P-450 enzyme system as a pathway for processing the medication face a threat or a risk.
One such medication that uses this specific pathway for processing medications is beta-blockers. So, CBD oil can interact with beta-blockers, and in turn, the effectiveness of both beta-blockers and CBD oil may be undermined.
Giving a clearer breakdown of this, the P-450 enzyme system breaks down toxins into substances the body can process.
These toxins include certain medications too. Taking CBD oil, along with natural compounds like grapefruits, has resulted in slowing down the metabolic process of the P-450 enzyme pathway.
CBD Inhibits Pathways
When the P-450 pathway is filled or occupied with something like CBD oil, the time taken for your body to process other things, like beta-blockers, is delayed.
This is because CBD inhibits the pathway’s ability to break down the medication and enable it to work in the body.
When the beta-blockers are not broken down, higher amounts of active ingredients stay in the system for a longer period. Not only that, but the active ingredients from beta-blockers also stay unmetabolized for longer in the P-450 pathway.
This delayed time required to process and metabolize beta-blockers increases the likelihood that you’d experience the side effects of the interaction.
So, it’s pretty clear, CBD oil can interact with beta-blockers, and the primary reason for this comes with CBD oil inhibiting your body’s ability to break down beta-blockers.
Side Effects of Combining CBD Oil and Beta Blockers
The side effects of taking CBD oil and beta-blockers include low to very low blood pressure.
This is because beta-blockers are designed in a way to reduce your heart rate by slowing down or preventing the release of the stress hormone “adrenaline.” This is primarily how beta-blockers help with lowering blood pressure and relieving stress.
On the other hand, CBD oil does the same thing. CBD oil relieves stress and is shown to be effective in lowering high blood pressure.
Nevertheless, CBD oil also amplifies the effects of beta-blockers. This means as beta-blockers reduce high blood pressure, CBD reduces the blood pressure even further.
This will result in your body lowering blood pressure beyond what would be considered healthy.
Feeling tired, lethargic, dizzy, and weak are some common symptoms of low blood pressure. In extreme cases, such as when your blood pressure reduces too much, you could faint or even move into a state of shock, which are all medical emergencies.
How to Safely Use CBD Oil with Beta-Blockers
As it’s clear, both CBD oil and beta-blockers reduce blood pressure levels, so the key to using both safely is to find the right balance.
To find the right balance, the first and foremost thing to do is consult your doctor.
You can also speak to a professional in alternative medicine who specializes in CBD-based medical treatments.
It would be typically recommended that if you were to combine CBD oil and beta-blockers that you start with the lowest dose possible. You can then gradually increase your dose if need be. However, you must consult your doctor for medical advice to ensure you are not putting yourself at any risk.
Tolerance to CBD Oil
Some patients find their body beginning to build a tolerance to CBD oil. This means that they can phase out the use of beta-blockers.
For this, you can try lowering the dose of beta-blockers and gradually increase your CBD oil dosage.
However, this must be done under the guidance and advice of your doctor.
For some, CBD oil might be seen as a natural alternative to beta-blockers, and this may be the case for you. But tread with caution. Beta-blockers can serve as a life-preserving medication and should not be messed with lightly.
So, before taking CBD oil and beta-blockers, always consult your doctor regarding any changes in these medications.
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CBD Drug Interactions – Mixing Cannabidiol and Medications
Are you worried about potential CBD-drug interactions? In this article, we explain the mechanism behind drug metabolism and how CBD may interfere with it.
The range of therapeutic properties offered by CBD (cannabidiol) has spurred its popularity in recent years. This natural compound is known to relieve a host of symptoms, allowing for safer and more effective management of different health conditions.
And unlike THC (tetrahydrocannabinol), CBD is non-intoxicating, so it won’t get you high.
CBD can assist in the treatment of anxiety disorders and depression, inflammation and pain, neurodegeneration, seizure disorders, sleep deprivation, metabolic conditions, neuropathy, migraines, inflammatory bowel disease, and more.
Considering CBD has so many potential health benefits, you may start wondering if it can interact with certain medications used to address the same symptoms — and whether you should or shouldn’t take these drugs with CBD.
Below you’ll find the dos and don’ts of using CBD along with medications.
Let’s start with the don’ts.
What Drugs Should Not Be Taken with CBD
Studies from the Indiana University Department of Medicine have provided a list of pharmaceutical drugs and medications which shouldn’t be taken with CBD.
The list below covers all groups of drugs that can negatively interact with CBD oil.
- Angiotension II Blockers
- Anticonvulsants / Anti-Seizure Medications
- Calcium Channel Blockers
- HIV Antivirals
- HMG CoA Reductase Inhibitors (Statins)
- Immune Modulators
- Non-Steroidal Anti-Inflammatory Drugs
- Oral Hypoglycemic Agents
- Proton-Pump Inhibitors (PPIs)
- Steroids and Corticosteroids
There’s also a group of drugs called “prodrugs” that first need to be processed into their therapeutic compounds instead of being therapeutic compounds on their own. In plain English, the inactive compound is consumed, and once in the body, it turns into the active compound.
If this mechanism is dependant on the CYP450 system (more on that later), a drug interaction can lead to insufficient concentrations of the therapeutic agent in the bloodstream — reducing its potency.
CBD Interaction with Drugs & Medications
This section covers the most common interactions between CBD and medications. If you take any of the substances listed below, make sure to consult your doctor before buying CBD oil.
CBD and Ibuprofen Interaction
Ibuprofen is one of the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), meaning it can produce similar benefits to CBD in terms of inflammation and pain relief. Previously we’ve mentioned that NSAIDs interact with CBD, which may raise concerns about potential negative interactions between CBD oil and Ibuprofen.
According to a study from the Journal of Neurology Research, there have been no reported interactions between CBD and ibuprofen, although it doesn’t mean they do not exist. Health experts suggest that potential interactions may be dosage-dependent. If a certain dosage threshold is breached, CBD and NSAIDs like Ibuprofen can lead to unforeseen and potentially severe nervous system pathology.
CBD and Adderall Interaction
A 2020 study found that higher doses of medical cannabis led to a decreased use of ADHD medication in adults. Products containing a higher concentration of CBD were linked to lower ADHD scores. This means that CBD can interact with ADHD meds, decreasing their efficacy while providing more pronounced benefits. The potential side effects of interactions between CBD and Adderall may lead to decreased appetite.
CBD and Lamictal Interaction
Using medical cannabis and Lamictal may increase side effects such as dizziness, confusion, drowsiness, and difficulty concentrating. Elderly consumers may also experience impairment in judgment. That being said, none of these side effects were proven to result from CBD use per se. When it comes to interactions between CBD and Lamictal, it can make the medication more or less effective, depending on the dosage.
CBD Oil and Antibiotics
There is no known interaction between CBD and antibiotics, although these interactions may occur if an antibiotic is metabolized through the cytochrome P450 enzyme system. Some studies indicate that taking CBD and antibiotics together may amplify the effects of one another without any negative side effects. However, more research is needed to confirm these findings on a larger scale.
CBD Oil and Omeprazole
CBD can inhibit the enzymes that are targeted by omeprazole and other Proton Pump Inhibitors (PPIs). Taking CBD with certain heartburn medications can increase the risk of diarrhea.
CBD and Thyroid Medications
Some people report mild nausea when taking CBD oil together with their thyroid medications. Since both substances are processed by the CYP450 enzyme system, taking CBD with a thyroid medication may cause hyperthyroidism because more thyroxine would be secreted than the body could metabolize.
CBD and Lisinopril
CBD can temporarily lower blood pressure, so taking it alongside medications like Lisinopril might reduce it even more, making you feel lethargic and weak. Always consult your doctor before adding CBD to your routine if you use anti-hypertension meds.
CBD and Prednisone
Since both CBD and corticosteroids are potent inhibitors of the CYP450 enzyme system, concomitant use may increase the risk of systemic side effects from corticosteroid use due to decreased glucocorticoid clearance. Corticosteroids like prednisolone and hydrocortisone should never be taken with CBD.
How Drugs Interact: Understanding Drug Metabolism
Metabolism can refer to how your body uses energy for weight management, or the way drugs are metabolized in your body.
The former is known as the basal metabolic rate, or in simple terms, the number of calories a person needs to maintain healthy body functions while at rest.
The latter is very different from the basal metabolic rate. Drug metabolism refers to how a substance is processed and used by the body — with the majority of this processing happening in the liver.
Scientists call it the ‘first-pass effect’ or ‘first-pass metabolism.’
Using straightforward terms, when you take a medication, it is broken down in the liver into its active compounds so that the body can use them. Just like carbohydrates are broken down into sugars, fats into triglycerides, and proteins into amino acids — drugs break down into their individual ingredients.
From there, they are controlled by specific enzymes, which transform these compounds into metabolites. These metabolites then influence different processes in your body and are flushed with urine once used up.
How Is CBD Metabolized?
Drug metabolism determines the rate at which the body processes medications and other therapeutic compounds into their individual metabolites and how long they can stay in your system.
When you take CBD in the form of an oil, capsule, or gummy, it has to pass through your gut, where it is released into the bloodstream. From then, they travel through the bloodstream to the liver, where it absorbs through the hepatic portal. The liver breaks CBD down into its metabolites using enzymes, after which it can circulate throughout the body in the bloodstream again.
What Is the Cytochrome P450 System?
Aside from breaking compounds down into metabolites, the liver also detoxifies and excretes foreign substances and other types of toxic compounds. This can happen through a system of enzymes referred to as the Cytochrome P450 (CYP450). These enzymes contain heme as a cofactor to convert cannabinoids into more water-soluble molecules, increasing their absorption and efficacy.
Researchers estimate that the CYP450 system is responsible for metabolizing 60% of any drugs out there. And interestingly, doctors and pharmacists use this system to understand, evaluate, and predict the benefits of the drug and potential side effects based on their dosages.
However, certain compounds have the ability to compromise the CYP system’s functioning, negatively affecting the metabolism of certain medications. Once these interactions occur, the drugs can be metabolized faster or slower than normal.
CBD And the Cytochrome P450 System
As mentioned earlier, CBD can interact directly with the CYP450 system in the liver. According to preclinical studies, CBD binds to the site where the enzyme activity occurs, competing with other compounds and thus preventing this system from breaking down other substances.
This inhibitory effect on the CYP450 enzymes mainly depends on how much CBD a person takes, their unique physiology, and the type of CBD used (e.g., full-spectrum CBD vs. CBD isolate). The dosage determines the strength used by the CBD to bind to the active site of the metabolic enzymes. The tighter the bond, the more competitive inhibition.
Contraindications for Taking CBD with Medications
The mechanism behind CBD’s health benefits proves that it’s not a biologically inert compound. Instead, the pharmacokinetics and pharmacodynamics of CBD are complex and similar to any other medication. Therefore, it has the potential to compromise the metabolism of certain medications.
Any therapeutic substance that relies on the CYP450 system can be potentially affected by CBD. A common indicator for such interaction is when your medication has a grapefruit warning on the bottle. However, this is by no means a solid point of reference, and you should always check with your doctor and pharmacist before taking the two compounds together.
Why You Should Always Consult Your Doctor First
The list of drugs that we’ve mentioned above is by no means definite and doesn’t include all the pharmaceutical substances that may interact with CBD. Similarly, not all the medication from these categories will necessarily cause an interaction — as is the case for antibiotics and Ibuprofen.
A consultation with a doctor experienced in CBD and cannabis use can help you establish the right routine for your medications and supplements to avoid potentially negative interactions. Some compounds work synergistically with CBD, so asking your doctor can help you maximize the effect of your treatment.
Not to mention that the doctor can guide you on finding the optimal dosage for yourself.
Key Takeaways on CBD Drug Interactions
The safety profile of CBD has been acknowledged by major health agencies, such as the World Health Organization (WHO), showing that it’s well-tolerated by animals and humans and rarely produces any dangerous side effects.
CBD also has a profound impact on an array of systems, which explains its therapeutic versatility. That being said, this versatility is also the reason why CBD interacts with so many prescription meds and over-the-counter (OTC) PRODUCTS.
Again, if you’re not sure if CBD will interact with the medication that you might be taking, a consultation with a health professional will not harm — unlike trying to figure out these interactions on your own.
Livvy is a registered nurse (RN) and board-certified nurse midwife (CNM) in the state of New Jersey. After giving birth to her newborn daughter, Livvy stepped down from her full-time position at the Children’s Hospital of New Jersey. This gave her the opportunity to spend more time writing articles on all topics related to pregnancy and prenatal care.
Beta Blockers and CBD Oil Interaction
Alone, CBD oil has been shown to lower blood pressure, help manage anxiety, and control inflammation. It’s therefore no wonder that people with heart conditions are trying to find a way to combine CBD oil with their existing medications like beta blockers.
If you’re interested in experiencing the benefits of this cannabinoid but aren’t sure if CBD oil interacts with beta blockers, here you’ll find an overview of what you need to know.
But before getting started, keep in mind the information on this page is meant to serve as an educational tool and should not be substituted for medical advice. Always speak to your doctor before trying CBD oil.
How Does CBD Oil Interact with Beta Blockers?
Like beta blockers, CBD oil lowers blood pressure and improves health in patients whose heart is under strain due to lifestyle factors, medical complications, or both. CBD oil has also been shown to help reduce anxiety , another condition doctors will often prescribe beta blockers for.
In fact, many people use CBD oil instead of beta blockers because it produces similar benefits at a lower cost and has relatively few side effects. However, if you are already using beta blockers for conditions like hypertension or anxiety and want to explore adding CBD oil into your routine, it’s important to understand how they interact with each other in your body.
Cannabidiol (CBD) is widely considered to be a safe, well-tolerated compound with very few unintended effects. However, because of its inhibition of the cytochrome P-450 enzyme system in the liver, it should be used cautiously if you take any medication that acts through this pathway, such as beta blockers.
The cytochrome P-450 enzyme system breaks down toxins, including certain medications, for the body to process. CBD oil, along with other natural compounds like those found in grapefruit, has been shown to slow down the activity of this system.
When the P-450 pathway is occupied with something like CBD, your body could take longer to process specific medications. So, if you’re taking beta blockers and CBD oil, it could result in a higher amount of the active ingredient in beta blockers to remain present and unmetabolized in your body for a longer period of time. This increases the likelihood of experiencing the side effects of the medication.
Because CBD oil can inhibit your body’s ability to break down beta blockers, it’s crucial to speak to your doctor before combining the two.
Side Effects of Combining CBD Oil and Beta Blockers
Beta blockers are designed to reduce heart rate by slowing or preventing the release of the stress hormone adrenaline. When effective, beta blockers lower blood pressure and relieve stress on the heart. CBD oil has also been shown to lower blood pressure and could amplify the effects of beta blockers.
If you take the two together, there’s a chance your blood pressure could drop too much, which may cause you to feel tired, lethargic, dizzy, and weak. In extreme cases, you could risk fainting or even going into shock, which is considered a medical emergency.
With two compounds reducing blood pressure, dosages may need to be adjusted for both the beta blocker and CBD oil to achieve the right balance if you decide to combine the two.
CBD Oil for Common Beta Blocker Side Effects
The most common side effects reported among beta blocker users are nausea and fatigue, and while CBD oil could possibly potentiate these effects, it may also help relieve them.
CBD oil has been shown to reduce the experience of nausea across a range of health conditions, from general motion sickness to chemotherapy-induced nausea . Many people also anecdotally report that feelings of nausea are negated by the effects of CBD oil. Therefore, if you feel nauseous after taking beta blockers, CBD oil may be able to help.
CBD is also being researched for its effect on wakefulness. Several studies have found that CBD taken in smaller doses increases wakefulness and alleviates daytime sleepiness caused by factors such as sleep apnea, substance abuse, or certain medications. If you’re experiencing drowsiness or fatigue as a result of your beta blockers, CBD oil in small doses could help.
How to Safely Use CBD Oil with Beta Blockers
When it comes to safely using CBD oil and beta blockers, slow and steady is the way to go. First and foremost, make sure to consult with your primary physician. You can also speak to a naturopathic doctor who specializes in CBD-based medical treatments.
Once you have the “all clear” from your doctor, start by taking a lower dosage of CBD oil than what is suggested on your product’s information leaflet. This will reduce the risk of experiencing a sudden drop in blood pressure.
If you aren’t seeing the beneficial effects of CBD you were expecting, and still feel your blood pressure is at a healthy level, you can gradually increase your dosage. Again, slow and steady wins the race.
Being mindful of how you feel after taking CBD oil with beta blockers will be crucial to ensuring you’re getting the desired results in the safest way possible. Logging your physical and cognitive energy levels on a scale of 1-10 with descriptions may be helpful after taking CBD oil with your beta blockers. If you start to notice your ratings are dropping, you should either reduce your CBD dosage or stop taking it entirely.
Many people find that as their body begins to build a tolerance to CBD oil, they are in a position to phase out the use of beta blockers. You may be able to accomplish this by carefully lowering your beta blocker dosage as you increase your CBD oil dosage. This should, of course, be done under the supervision and guidance of your doctor.
For more information about CBD oil dosage, check out our dosage guide here.
Best CBD Oils to Use with Beta blockers
All CBD oil products are not created equal, and finding the best CBD oil to use with beta blockers requires doing your due diligence. While this may seem to be an overwhelming prospect, it really isn’t so difficult.
First, decide on the method you’d prefer for taking CBD oil. There are a variety of options including capsules, tinctures, edibles , transdermal patches, and vapes. Most people who are new to CBD oil tend to opt for capsules for the familiarity, convenience, and dose consistency. But keep in mind that this method, along with CBD edibles, releases CBD into the body via the digestive system, with some potency lost in the process. A tincture, meanwhile, comes in dropper form and when applied under the tongue, is absorbed directly into the bloodstream. Vapes will provide you the fastest-acting but shortest-lasting effects of CBD and are ideal for on-the-go doses. Transdermal patches will provide you with the longest lasting distribution of CBD; however, because it’s a relatively large dose over a long period of time, you will want to be careful about combining this method with beta blockers.
Once you’ve settled on a method, do your research on the product itself. Choose a product which has been organically-grown and third-party laboratory tested. This ensures that the CBD oil is free from harmful pesticides and that its content has been tested without bias. Read any posted Certificates of Analysis to ensure the listed potency of the product is correct, and so you know exactly what is in the final product. If a brand does not post a Certificate of Analysis for the product you’re interested in, ask to see it. If they do not provide one, you should know to shop elsewhere.