Cannabis may present novel and effective treatment options research for overactive bladder syndrome. Incontinence and urine loss cause social as well as physical discomforts, but CBD Oil can help control both their causes and consequences. Overactive bladder syndrome or OAB is a medical condition where a person experiences an uncontrollable urge to urinate.
Cannabis & Incontinence
Scissor-walks and stutter-steps: the familiar dance performed by nearly 33 million Americans suffering from Overactive Bladder ( OAB ) – also known as Spastic Bladder and Detrusor Overactivity. OAB tends to plague people struggling with Multiple Sclerosis ( MS ) or other neurodegenerative diseases. While not exactly a given as we age, OAB also seems to affect a disproportionate number of older women and men.
Currently, two types of medications are available to treat OAB – antimuscarinics and Mirabegron (Myrbetriq). Doses of these powerful drugs must be carefully controlled. But even when used properly, these drugs can generate dry mouth, constipation, dry or itchy eyes, blurred vision, indigestion, urinary tract infection, urinary retention, drowsiness, high blood pressure and headaches. Taking too much accidentally can have more serious consequences, resulting in heart rhythm changes, hallucinations, seizures, and coma.
Because bladder control falls mostly to the central nervous system, it’s no surprise that cannabis may present novel and effective treatment options. We know that cannabinoid receptors are profusely expressed in both the central nervous system and peripheral nervous system. And we also know that these receptors are activated by endogenous compounds as well as components of the cannabis plant. Thanks to ongoing research on cannabis and MS , quite a bit of useful data about incontinence has been collected, both in preclinical studies and a few small clinical trials.
How bladder control works
The bladder is a pretty simple structure as far as organs go. Its major component is the smooth detrusor muscle. To facilitate urination, the lower detrusor muscle – located near the bottom of the bladder and contiguous with the urethral sphincter that controls outflow – contracts. During the filling stage, the detrusor remains relaxed and the sphincter closed.
The role of the central nervous system in continence appears to be fairly straightforward. Neural circuits in the brain and spinal cord enable the healthy function and voluntary control of the bladder. According to research at the University of Pittsburgh School of Medicine, “The central nervous mechanisms controlling the LUT [lower urinary tract] are organized in the brain and spinal cord as simple on-off switching circuits that are under voluntary control.”
Neural circuits in the brain and spinal cord enable the healthy function and voluntary control of the bladder.
However, as reported in the journal Urology, “Damage to central inhibitory pathways or sensitization of peripheral afferent terminals [nerve fibers] in the bladder can unmask primitive voiding reflexes that trigger bladder overactivity.”
Summarized, this means that after we’ve been potty trained, we can control our bladders through the sensory inputs and our intent. But with overactive bladder conditions, communication through the nervous system between bladder and brain goes a little haywire. Fortunately, it looks like medical science is poised to make a breakthrough by targeting our endocannabinoid system.
Endocannabinoids and bladder function
The bladder and its surrounding layers contain both types of cannabinoid receptors — CB 1 and CB 2. A 2017 report by South Korean scientists showed that detrusor overactivity can be affected by known agonists (activators) of the two cannabinoid receptors. In the urothelium, where the smooth detrusor muscle cells meet the sensory neurons, CB 1 activity exhibited special promise as a modulator in cases of OAB .
Human studies have shown that cannabis treatments decrease incontinence episodes.
A precise understanding of the pathways of cannabinoid remediation of OAB remains up for debate and more study, but the evidence emerging from ongoing research is that cannabis therapeutics can certainly play a beneficial role.
Given that most medications designed to treat OAB act to calm the nerves, it makes sense that cannabis, an anti-anxiety botanical, could confer a similar effect. In a detailed 2017 meta-analysis of the scientific literature, a team of European scientists screened thousands of articles in search of quality human trials. They found three, and those studies used either tetrahydrocannabinol ( THC ) or a combination of THC and cannabidiol ( CBD ) to study efficacy against overactive bladder in MS patients.
THC and CBD in human incontinence trials
The meta-analysis describes two random controlled trials and one open label trial comprising 426 male and female MS patients. They were treated with THC / CBD , administered either by capsule or oromucosal spray. The scientists found that the cannabis treatments “relevantly decreased incontinence episodes in all three studies.”
No side effects were reported in the tablet trials, but some of those who received the spray reported dizziness, headaches, vomiting, dry mouth and urinary tract infection. These side effects were considered mild compared to conventional treatments. Whether the administered drugs were synthetics, natural plant extracts or both was not reported in the meta-analysis.
The possibility of safe and effective cannabis-derived remedies for incontinence (without harsh side effects) spurs excitement in the holistic health community. However, it remains to be seen if CBD isolate or CBD -rich hemp with little or no THC will prove to be as effective as CBD combined with THC for OAB patients.
Linda M. June writes for the natural health and wellness community. She can be found at TheLetterista.com.
Copyright, Project CBD . May not be reprinted without permission.
CBD Oil against urine loss and incontinence
Incontinence is a lot more common than you might think. It´s a very unpleasant problem, with more than just physical discomfort. Urine loss and its implications can also lead to emotional suffering. Your social life and relationship can be severely affected and you may develop feelings of anxiety or shame: the problem is not age-related and it can affect anyone. What can CBD Oil do against incontinence and how can it help your bladder to function better? Find out here!
How does a healthy bladder function?
The urine produced by the kidneys, flows through the urethra to the bladder. The bladder is surrounded by layers of muscle tissue that stretch to hold urine. A bladder holds the urine that arrives from the kidneys. When the bladder is full, your brain will receive a signal: you have to pee. In order to urinate, the bladder muscles squeeze and two valves will open, so the urine can flow out.
What is incontinence and what can cause it?
When hearing the word incontinence, many people think it has something to do with ‘peeing your pants’. Incontinence is, in fact, ‘the involuntary loss of urine’ and it’s a common problem. In Western countries, 15% of all people suffers from incontinence. Although incontinence or urine loss is often associated with elderly people, it can occur in all ages and affects both men and women.
Urge incontinence occurs when the urge to pee is very strong and unexpected, which makes it too difficult to reach the toilet in time. The bladder can be extra irritable and is sometimes called ‘overactive’. The bladder muscles contract very suddenly, causing all the urine to flow from the bladder. This can turn your day into a constant struggle against your own bladder in order not to lose urine.
Urge incontinence can be caused by bladder disorders such as urinary tract infection (UTI) or an enlarged prostate as well as Multiple Sclerosis (MS) and Parkinson’s disease. Unfortunately, sometimes it’s medically impossible to establish a cause for urge incontinence.
Stress incontinence is also called overflow incontinence. As the word suggests, the bladder doesn’t empty itself completely, but your bladder leaks small amounts of urine during activities that cause pressure on the belly. Things like coughing, sneezing, laughing, lifting heavy things or exercise are examples of activities that can cause sudden pressure on the belly. With this form of incontinence, the bladder’s sphincter muscles do not function properly.
What are the physical and emotional implications of incontinence?
The involuntary loss of urine is a very unpleasant problem. Aside from the shame you may feel, physical issues may occur. For example, the loss or urine can lead to skin problems. Urine irritates the skin quickly and can cause redness or an itchy skin.
Apart from the nasty inconveniences and physical implications, there can also be a great impact on the quality of daily life. Some people tend to leave their house less often, because they are afraid they will lose urine in public. Tensions arise and even anxiety can occur, which can lead to a lack of self-confidence. Incontinence can also lead to relationship problems or problems in the sexual sphere.
How can you treat incontinence with regular medication?
Conventional medicine has several options for treating incontinence and urine loss, but the associated side-effects make a natural supplement like CBD Oil an attractive alternative.
The medication that’s being used to treat urge incontinence is anti-cholinergic agent. This relaxes the overactive bladder muscles, so the bladder can hold more urine, which delays the urge to urinate. Furthermore, the medicine also inhibits the involuntary contraction of the bladder muscles.
Side effects: dry mouth, coughing, nausea, dizziness and headache.
Duloxetine is a medicine that causes the bladder sphincters to strengthen. This reduces the unwanted loss of urine.
Side effects: gastrointestinal problems, nausea, constipation, dry mouth, headache, fatigue and drowsiness.
Overactive bladder muscle
Botulinum Toxin A is sometimes administered to people with overactive bladder muscles. The medication is injected, in very small amounts, directly into the bladder wall. This paralyzes the nerve that controls the bladder muscle, to prevent the muscle from contracting too strongly and sudden. This should ensure that you need to urinate less frequently and that the bladder is more capable of holding the urine.
Side effects: swallowing difficulties, drooping eyelid, ear infection, pain, virus infection and muscular weakness.
Luckily, then, it seems as if cannabidiol from natural hemp plant origins can be used to treat urine loss issues without such unpleasant side effects.
CBD Oil, urine loss, and incontinence
First, let’s take a look at how CBD can team up with your body. Then we will explain how CBD Oil can help with specific bladder problems and incontinence.
CBD Oil and the ECS
CBD is short for cannabidiol. It’s a compound found in the hemp plant and it’s one of the many cannabinoids the plant produces. Unlike THC, another cannabinoid, CBD isn’t psychoactive, so it doesn’t make you high.
All important processes in your body are controlled by the endocannabinoid system (ECS). The task of the ECS is to keep all other systems in your body in balance and to ensure important processes keep running smoothly. Scientists discovered that there are endocannabinoid receptors all through the body. They are situated in, among others, the brain, the skin, the bones, the immune system, the liver, in muscles, blood vessels and in the guts. In fact, the ECS is a system that affects almost every part of the body.
CBD is recognized by your body as a cannabinoid, so it can work together with the receptors of the ECS. In that way, CBD can have a big influence on many important processes.
CBD Oil and the bladder
All over the bladder, the tissues and muscles around it, are endocannabinoid receptors. Research showed that CBD can be effective for an overactive bladder muscle.
How can CBD Oil help people with incontinence?
Interestingly, CBD Oil can help control both the social and physical consequences of urine loss and incontinence. That means you can now use a natural, plant-based supplement to keep these common discomforts from ruining your day!
CBD Oil to relax body and mind
When you suffer from urge incontinence, your bladder muscles are too active. These muscles contract at an unexpected, and probably inconvenient, moment.
CBD Oil has soothing properties. Just like the regular medication, CBD can help to relax the overactive muscles of the bladder, so the bladder can hold more urine. CBD can also help to prevent the sudden and unexpected contraction of the bladder wall.
Do you suffer from social anxiety, because you´re afraid someone will notice your incontinence problems? CBD Oil can help you when suffering from the implications of incontinence. The oil can help to relax your body and mind, so it gets easier to interact with others. You worry less, your emotions can settle and you get the feeling you can trust yourself and your body again.
CBD Oil against skin irritation caused by incontinence
Urine loss can lead to skin irritation. The skin in the intimate area is very sensitive and some substances in the urine can quickly cause redness, itchiness, pain or even infections. We don’t recommend to use our CBD Skincare Products for the the intimate zone, but thankfully, CBD Oil has another way to help your skin!
CBD can influence all important physiological processes by working together with the ECS. This means CBD can also influence the functioning of our skin cells. Shortly put: CBD can help to relax your skin from within your body, so the complaints of the skin irritation will quickly get relieved.
The natural benefits of CBD Oil
CBD Oil is safe to use. The WHO (the World Health Organization) has stated in 2017 that cannabidiol isn’t addictive or harmful if used regularly. Besides this, CBD has no psychoactive effects. Our Full Spectrum CBD Oil contains only a very small amount of THC – less than 0,03% – which is not remotely enough to get you high.
Regular medication that is prescribed by the doctor to relieve incontinence problems, can have severe side effects. Generally, CBD Oil doesn’t cause side effects. Still, keep in mind that every human body is unique and everyone can respond in a different way to a certain substance. There are some mild side effects you could encounter when using CBD Oil: dizziness, nausea, dry mouth, drowsiness and loss of appetite.
Usually you don’t have to worry about this. It can be a sign that your body has to get used to the CBD. Lower your daily dose for a couple of days and see if it helps.
Which CBD Product is right for you?
As said, every human being is different, both physically and in terms of preferences. Luckily, we have a full range of first-class CBD supplements for you to pick your perfect personal match. Will you choose our Full Spectrum CBD Oil, or would you rather go for the convenience of CBD Tablets, or try our delicious CBD Nutrition?
Select your CBD match here
Whichever supplement you choose, you can rely on the natural quality of SupMedi CBD. We use only the finest ingredients and have all our products tested for purity in independent laboratories. Feel free to explore the possibilities of CBD for your body and to discover which CBD product and individual dose is right for you!
CBD for Overactive Bladder – August 2022
Overactive bladder syndrome or OAB is a condition where one feels an uncontrollable and sudden urge to urinate.
OAB or urinary incontinence is caused when the bladder muscles or detrusor muscles involuntarily contract. These contractions can cause a person to urinate regardless of urine volume in the bladder.
Some conditions that may cause a person to experience OAB include diabetes, urinary tract infections, bladder stones or tumors, stroke, Parkinson’s d isease, multiple sclerosis (MS) , or hormonal changes.
A person with OAB may pass urine several times a day. Persons with this condition may experience emotional stress, interrupted sleep cycles, or sexuality issues affecting their social or work life (4) .
Some behavioral changes may allow a person to manage OAB and improve bladder control and overall wellness.
These changes include engaging in physical activity, exercising the pelvic floor muscles, maintaining a healthy diet, scheduling urination , and limiting smoking and consumption of alcohol (5) .
For OAB , other treatment options include taking prescription drugs, Botox injections, nerve stimulation, and surgery (6) .
Prescription drugs for OAB include oxybutynin, tolterodine, solifenacin, darifenacin, or fesoterodine. Oxybutynin may be taken as a pill or used as a gel or skin patch (7) .
What Studies Say About CBD ’s Effects on the Bladder
A pilot study by Maniscalco , Aponte , Bruzzese , and other researchers on the effects of cannabidiol on patients with multiple sclerosis OAB was conducted in 2017.
The researchers conducted clinical trials on several MS patients and evaluated leakage , detrusor muscle pressure, and spasticity .
The observation was done before and after tetrahydrocannabinol – cannabidiol oromucosal spray was applied to the patients.
Urodynamic findings after the treatment indicated a significant reduction of post-void residual volume. Bladder volume at the first desire and maximal cystometric capacity also increased. However, the amounts were insignificant.
The results showed that THC – CBD oromucosal sprays may improve bladder symptoms and detrusor overactivity (8) .
A 2010 review was published in the Indian Journal of Urology on the role of cannabinoid receptors in the bladder . T he researchers said that endocannabinoid receptors CB 1 and CB 2 in the bladder periphery may contribute to controlling bladder stimulus (9) .
Cannabinoids extracted from the Cannabis plant , like CBD , CBG , and THC , affect the CB 1 and CB 2 receptors . Unlike THC , CBD has no psychoactive effect characterized by a high sensation.
As of 2021, CBD has only been approved by the FDA to treat epilepsy (10) . Studies are still ongoing to determine and confirm the efficacy of CBD and medical marijuana on OAB .
How CBD Lowers Inflammation and Urinary Frequency
CBD may help manage various illnesses like neuroinflammation, epilepsy, vomiting and nausea, oxidative injury, and anxiety (11) .
Neuroinflammation is an inflammatory response in the central nervous system associated with various diseases like multiple sclerosis and stroke (12) . These diseases are some of the conditions that can trigger bladder dysfunctions like OAB .
CBD works by interac ting with the endocannabinoid system. The ECS contains receptors that regulate various body functions (13) , like CB 1 receptors in the central nervous system responsible for regulating inflammatory responses.
Can CBD Be Used to Manage Overactive Bladder Conditions?
The study by Maniscalco and colleagues showed that CBD as an oromucosal spray may effectively manage OAB (14) .
More clinical trials must be conducted to determine if other CBD oil products are as effective as THC – CBD oromucosal sprays .
How CBD Works on the Bladder
CBD may affect the bladder through the ECS, particularly the CB 1 and CB 2 receptors . This effect may help with controlling bladder stimulus (15) .
CBD also affects the ECS receptors that regulate inflammatory responses triggered by various neurological conditions like MC or stroke. These neurological conditions are known to cause OAB (16) .
Does CBD Create a Positive Effect on the Bladder?
The results from the 2017 study by Maniscalco and his team showed that CBD may have a favorable impact on detrusor muscle activity and help manage OAB symptoms (17) .
CBD is well tolerated and does not have the same psychoactive effects as THC , although both compounds are Cannabis extracts. However, the use of CBD may still cause side effects like diarrhea, reduced appetite, dry mouth , and fatigue (18) .
Patients with OAB are encouraged to consult a physician or professional health worker to determine if CBD is a practical option in managing OAB .